CXCR7 Agonist TC14012 Improves Angiogenic Function of Endothelial Progenitor Cells via Activating Akt/eNOS Pathway and Promotes Ischemic Angiogenesis in Diabetic Limb Ischemia.
Kai WangShiyue SunGuigui ZhangZixian LuHui ChenXia FanChunjie GuXiaohong PanQian LinOscar ChenLu CaiXiaozhen DaiXiao WangChaosheng LuXiaoqing YanYi TanPublished in: Cardiovascular drugs and therapy (2022)
TC14012 can prevent EPCs from HG-induced dysfunction and apoptosis, improve eNOS activity and NO production via CXCR7/Akt signal pathway, and promote EPC mobilization and diabetic ischemia angiogenesis.
Keyphrases
- endothelial cells
- high glucose
- signaling pathway
- wound healing
- pi k akt
- oxidative stress
- cell cycle arrest
- type diabetes
- cell proliferation
- vascular endothelial growth factor
- nitric oxide synthase
- endoplasmic reticulum stress
- cell migration
- cell death
- ischemia reperfusion injury
- nitric oxide
- fluorescent probe
- brain injury
- aqueous solution
- cerebral ischemia