BthTX-I from Bothrops jararacussu induces apoptosis in human breast cancer cell lines and decreases cancer stem cell subpopulation.

Patrícia Heloise Alves BezerraIsadora Marques FerreiraBeatriz Tinoco FranceschiFrancine BianchiniLuciana AmbrósioAdélia Cristina O CintraSuely Vilela SampaioFabíola Attié de CastroMaria Regina Torqueti

Published in: The journal of venomous animals and toxins including tropical diseases (2019)

BthTX-I induces apoptosis and autophagy in all breast cancer cell lines tested and also reduces CSCs subpopulation, which makes it a promising therapeutic alternative for breast cancer.

Keyphrases

cancer stem cells
endothelial cells
cell death
signaling pathway
endoplasmic reticulum stress
young adults