Pressure-Driven Insulin Release Overcomes Limitations of Diffusion for Encapsulated Islet Cell Therapy.

Ella A ThomsonRayhan A LalHaixia XuSooyeon LeeHannah MoellerJustin P AnnesAda S Y Poon

Published in: bioRxiv : the preprint server for biology (2023)

Diffusion-based insulin delivery from macroencapsulated islet cells is incompatible with physiologic glucose control, a constraint addressed through pressure-based insulin delivery.

Keyphrases

cell therapy
type diabetes
glycemic control
induced apoptosis
stem cells
mesenchymal stem cells
blood glucose
signaling pathway
cell proliferation
oxidative stress
endoplasmic reticulum stress
adipose tissue
skeletal muscle