Acetylshikonin suppressed growth of colorectal tumour tissue and cells by inhibiting the intracellular kinase, T-lymphokine-activated killer cell-originated protein kinase.

Ran ZhaoBu Young ChoiLixiao WeiMangaladoss FredimosesFanxiang YinXiaorong FuHanyong ChenKangdong LiuJoydeb Kumar KunduZigang DongMee-Hyun Lee

Published in: British journal of pharmacology (2020)

Acetylshikonin suppressed growth of colorectal cancer cells by attenuating TOPK signalling. Targeted inhibition of TOPK by acetylshikonin might be a promising new approach to the treatment of colorectal cancer.

Keyphrases

protein kinase
induced apoptosis
single cell
signaling pathway
cell cycle arrest
cancer therapy
stem cells
tyrosine kinase
cell death
mesenchymal stem cells
smoking cessation
pi k akt