A Comprehensive Review on Inorganic Nanoparticles as Effective Modulators of Amyloidogenesis.

Many degenerative disorders have started to develop as a result of the deposition of insoluble protein fibrillar clumps known as amyloid. This deposition mostly limits normal cellular function and signaling. This build-up of amyloid in-vivo results in a variety of illnesses in the body, including type 2 diabetes, several neurodegenerative diseases (such as Alzheimer's disease and spongiform encephalopathy), and Alzheimer's disease. Growing interest has been demonstrated in nanoparticles as potential treatments for amyloidosis throughout the past few decades. Inorganic nanoparticles are one of them and have also been substantial research as potential anti-amyloid drugs. Inorganic nanoparticles have emerged as good study candidates because of their reduced size, distinctive physical characteristics, and capacity to traverse the blood-brain barrier. In the current review, we will focus on the effects of different types of inorganic nanoparticles on amyloidogenesis and attempt to understand their underlying mechanism of action.