Light-Driven Self-Cascade Peroxidase-like Nanozymes without Exogenous H 2 O 2 .

The peroxidase (POD)-like nanozyme typically requires the addition of exogenous H 2 O 2 . To address the limitation, previous work mainly adopted a cascade strategy for H 2 O 2 production. Herein, we propose a new light-driven self-cascade strategy to construct POD-like nanozymes without exogenous H 2 O 2 . The model nanozyme resorcinol-formaldehyde resin-Fe 3+ (RF-Fe 3+ ) is synthesized with the hydroxyl-rich photocatalytic material RF as the carrier to in situ chelate metal oxides, which can simultaneously achieve the functions of in situ H 2 O 2 generation under irradiation and substrate oxidation via POD-like behavior. Notably, RF-Fe 3+ exhibits high affinity to H 2 O 2 , attributed to the excellent adsorption ability and hydroxyl-rich feature of RF. Furthermore, the dual photoelectrode-assisted photofuel cell was further constructed with a high-power density of 120 ± 5 μW cm -2 based on the RF-Fe 3+ photocathode. This work not only demonstrates the new self-cascade strategy of in situ generation of catalysis substrates but also provides an opportunity to extend the catalytical field.