A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.
Silke NuberAlice Y NamMolly M RajsombathHaley CirkaXiaoping HronowskiJunmin WangKevin HodgettsLiubov S KalinichenkoChristian P MüllerVera LambrechtJürgen WinklerAndreas WeihofenThibaut ImberdisUlf DettmerSaranna FanningDennis J SelkoePublished in: Annals of neurology (2020)
Prolonged reduction of brain SCD activity prevented PD-like neuropathology in multiple PD models. Thus, an orally available SCD inhibitor potently ameliorates PD phenotypes, positioning this approach to treat human α-synucleinopathies. ANN NEUROL 2021;89:74-90.