Absence of Subcerebral Projection Neurons Is Beneficial in a Mouse Model of Amyotrophic Lateral Sclerosis.
Thibaut BurgCharlotte BicharaJelena Scekic-ZahirovicMathieu FischerGeoffrey Stuart-LopezAurore BrunetFrançois LefebvreMatilde Cordero-ErausquinCaroline RouauxPublished in: Annals of neurology (2020)
Major corticofugal tracts are crucial to the onset and progression of amyotrophic lateral sclerosis. In the context of the disease, subcerebral projection neurons might carry detrimental signals to their downstream targets. In its entirety, this study provides the first experimental arguments in favor of the corticofugal hypothesis of amyotrophic lateral sclerosis. ANN NEUROL 2020;88:688-702.