Heterogenous nature of gene expression patterns in BRAF-like papillary thyroid carcinomas with BRAFV600E.

Groups of BRAF-like, BRAFV600E-positive cPTCs and fvPTCs that are homogenous in regard to histopathology, driver mutation and BRS were found to be highly heterogenous in terms of gene expression patterns. Yet, among the genes that were annotated with the terms containing the word "extracellular" and frequently over-/underexpressed, LIPH is a favorable prognostic marker for PTCs.