Autophagy markers LC3 and p62 accumulate in immune-mediated necrotizing myopathy.
Francesco GirolamoAnna LiaTiziana AnneseMargherita GianniniAngela AmatiDario D'AbbiccoMarilina TampoiaDaniela VirgintinoDomenico RibattiLuigi SerlengaFlorenzo IannoneMaria TrojanoPublished in: Muscle & nerve (2019)
The detection of LC3b+ or p62+ myofibers could be used in differentiating IMNM from PM. The identification of autophagy-modifying molecules potentially could improve patients' outcomes. Muscle Nerve, 2019.
Keyphrases
- end stage renal disease
- cell death
- ejection fraction
- endoplasmic reticulum stress
- oxidative stress
- signaling pathway
- newly diagnosed
- chronic kidney disease
- air pollution
- mass spectrometry
- skeletal muscle
- prognostic factors
- particulate matter
- late onset
- magnetic resonance imaging
- metabolic syndrome
- patient reported outcomes
- computed tomography
- liquid chromatography
- loop mediated isothermal amplification
- polycyclic aromatic hydrocarbons
- sensitive detection
- high resolution mass spectrometry