Effects of Urethritis on Human Immunodeficiency Virus (HIV) in Semen: Implications for HIV Prevention and Cure.
Jane S ChenMitch MatogaCecilia MassaGerald TeghaBeatrice NdalamaNaomi BonongweEsther MathiyaEdward JereGabriel BandaAmy J LoftisKathryn E LancasterWilliam C MillerIrving F HoffmanMyron S CohenPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
An HIV cure requires the elimination of HIV from every body compartment, but available ART does not currently accomplish this. Our study highlights the male genital tract as a local source of HIV that can be reversibly activated. A better understanding of this phenomenon is important to advance the HIV cure field.