A combined transcriptome and proteome analysis extends the allergome of house dust mite Dermatophagoides species.

Véronique Bordas-Le FlochMaxime Le MignonLaetitia BussièresKarine JainArmelle MarteletVéronique Baron-BodoEmmanuel NonyLaurent MascarellPhilippe Moingeon

Published in: PloS one (2017)

Using combined transcriptome and immunoproteome approaches, we provide a comprehensive characterization of D. farinae and D. pteronyssinus allergomes. We expanded the known allergen repertoire for D. pteronyssinus and identified two novel HDM allergens, now officially referred by the International Union of Immunological Societies (IUIS) Nomenclature Subcommittee as Der f 36 and Der p 36.

Keyphrases

rna seq
single cell
genome wide
gene expression
allergic rhinitis
health risk assessment
risk assessment
human health
polycyclic aromatic hydrocarbons
heavy metals