Disulfiram Relieves Severe Acute Pancreatitis by Inhibiting GSDMD-Dependent NETs Formation.

Xin LingChi NieLi Ping ShengChao Qun HanZhen Ding

Published in: Journal of digestive diseases (2023)

NETs are highly associated to the inflammatory injury of SAP. DSL inhibits NETs formation by down-regulating GSDMD, which in turn relieves the inflammation of SAP. Our study provides a possible therapeutic target for SAP.

Keyphrases

oxidative stress
signaling pathway
early onset