Is Dosing of Ethambutol as Part of a Fixed-Dose Combination Product Optimal for Mechanically Ventilated ICU Patients with Tuberculosis? A Population Pharmacokinetic Study.

Francisco Beraldi-MagalhãesSuzanne L ParkerCristina SanchesLeandro Sousa GarciaBrenda Karoline Souza CarvalhoMariana Millan FachiMarcus Vinicius de LizRoberto Pontarolo Jeffrey LipmanMarcelo Cordeiro-SantosJason Alexander Roberts

Published in: Antibiotics (Basel, Switzerland) (2021)

ICU patients displayed significantly different pharmacokinetics for an oral fixed-dose combination administration of ethambutol compared to outpatients, and neither patient group consistently achieved pre-defined therapeutic exposures.

Keyphrases

intensive care unit
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
mechanical ventilation
air pollution
peritoneal dialysis
hiv aids
pulmonary tuberculosis