Bezafibrate induces hypothyroidism in a patient with resistance to thyroid hormone β due to a G347R variant.

Ichiro YamauchiTakafumi YamashitaTaku SugawaTetsuya TagamiIkuko HanaokaTakeshi UsuiKeisho HirotaTakuro HakataYohei UedaToshihito FujiiYoriko SakaneAkihiro YasodaNobuya Inagaki

Published in: Clinical endocrinology (2021)

While hypothyroidism associated with BZ treatment did not occur in non-RTHβ patients, it was observed in a patient with RTHβ due to the p.G347R variant. Liver DIO3 upregulation might involve this hypothyroidism.

Keyphrases

replacement therapy
end stage renal disease
case report
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
cell proliferation
peritoneal dialysis
signaling pathway
patient reported outcomes
patient reported