Molecular detection of hepatitis B virus genotype E with immune escape mutations in chronic hepatitis B patients on long-term antiviral therapy in Jos, Nigeria.

Joseph A Anejo-Okopi Edith Okeke Pantong M Davwar Chika Kingsley Onwuamah Harris Onywera Patience Omaiye Mary Duguru Ocheme J Okojokwu Otobo I Ujah Bulus Jonathan Chima A George Ramyil S Crown Fiyaktu B Yakubu Judith O Sokei Leona C Okoli Onyemocho Audu Seth C Inzaule Isaac Okoh Abah Patricia A Agaba Oche O Agbaji Atiene S Sagay Claudia A Hawkins

Published in: African journal of laboratory medicine (2022)

This study revealed exclusive dominance of genotype E in Nigeria. The S gene mutations G145A and L271R are known to be associated with modified antigenicity and impaired serologic assays, which may cause false negatives in the detection of anti-HBV surface antigen. The presence of mutants that are associated with vaccine immune escape may also have diagnostic and vaccine immune response implications.

Keyphrases

hepatitis b virus
immune response
liver failure
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
dendritic cells
stem cells
patient reported outcomes
sars cov
mesenchymal stem cells
loop mediated isothermal amplification
wild type