C2orf40 inhibits metastasis and regulates chemo-resistance and radio-resistance of nasopharyngeal carcinoma cells by influencing cell cycle and activating the PI3K/AKT/mTOR signaling pathway.
Zuozhong XieWei LiJingang AiJun XieXiaowei ZhangPublished in: Journal of translational medicine (2022)
The results clarified the biological functions and mechanisms of C2orf40, as a tumor suppressor gene, in NPC, and provided a potential molecular target for improving the sensitivity of NPC to radiotherapy and chemotherapy.
Keyphrases
- cell cycle
- signaling pathway
- induced apoptosis
- locally advanced
- cell proliferation
- pi k akt
- cell cycle arrest
- early stage
- rectal cancer
- epithelial mesenchymal transition
- radiation therapy
- squamous cell carcinoma
- endoplasmic reticulum stress
- genome wide
- oxidative stress
- copy number
- gene expression
- cancer therapy
- cell death
- single molecule
- genome wide identification