The genetic link between systemic autoimmune disorders and temporal lobe epilepsy: A bioinformatics study.
Mahdi MalekpourSeyed Reza SalarikiaMohammad KashkooliAli Akbar Asadi-PooyaPublished in: Epilepsia open (2023)
The shared genetic variations (i.e., rs16944 on the IL-1β gene and ε4 variation of the APOE gene) may explain the underlying pathomechanisms of the comorbidity between three common SADs (i.e., IDDM, SLE, and RA) and TLE. Exploring such shared genetic variations may help find targeted therapies for patients with TLE, especially those with drug-resistant seizures who also have comorbid SADs.
Keyphrases
- drug resistant
- genome wide
- copy number
- temporal lobe epilepsy
- multidrug resistant
- acinetobacter baumannii
- dna methylation
- systemic lupus erythematosus
- disease activity
- multiple sclerosis
- rheumatoid arthritis
- genome wide identification
- gene expression
- type diabetes
- pseudomonas aeruginosa
- systemic sclerosis
- drug induced
- cystic fibrosis
- idiopathic pulmonary fibrosis