A phenotypic screening bioassay for Escherichia coli stress and antibiotic responses based on Fourier-transform infrared (FTIR) spectroscopy and multivariate analysis.

Bernardo Ribeiro da CunhaL P FonsecaC R C Calado

Published in: Journal of applied microbiology (2019)

Highly optimized FTIRS bioassay parameters are vital in capturing whole-spectra metabolic signatures that can be used for satisfactory and reproducible phenotypic screening of stress and antibiotic responses.

Keyphrases

escherichia coli
stress induced
high resolution
single molecule
genome wide
data analysis
dna methylation
cystic fibrosis