A Mouse Model of the Protease Activated Receptor 4 (PAR4) Pro310Leu Variant has Reduced Platelet Reactivity.
Xu HanElizabeth A KnaussMaria de la FuenteWei LiRonald A ConlonDavid F LePageWeihong JiangStephanie A RennaSteven E McKenzieMarvin T NiemanPublished in: bioRxiv : the preprint server for biology (2023)
A mouse model was created to represent the PAR4-P310L sequence variant.PAR4-P322L leads to reduced platelet reactivity in response to PAR4-activation peptide and thrombin, while the ADP and GPVI signaling pathways were unaffected.The PAR4-P322L mutation decreases time to occlusion in a mouse model of arterial thrombosis.The PAR4-P322L mouse model provides a foundation to further explore the role of PAR4 in hemostasis and thrombosis.