Concurrent tandem catalysis enabled by nanomechanical motion in heteroleptic four-component dual-catalyst machinery.

When the basic ligand 3 was added to the heteroleptic three-component slider-on-deck [Ag 3 (1)(2)] 3+ (sliding frequency k 298 = 57 kHz), it operated as a moderate brake pad ( k 298 = 45 kHz). Due to motion in the resulting four-component slider-on-deck [Ag 3 (1)(2)(3)] 3+ , both ligand 3 and silver(I) were continuously exposed and became catalytically active in a concurrent tandem Michael addition/hydroalkoxylation.