Alum impairs tolerogenic properties induced by allergoid-mannan conjugates inhibiting mTOR and metabolic reprogramming in human DCs.

Cristina Benito-VillalvillaIrene SoriaMario Pérez-DiegoEnrique Fernandez-Caldas José Luis Subiza Óscar Palomares

Published in: Allergy (2019)

We uncover novel mechanisms by which alum impairs the tolerogenic properties induced by PM, which might well contribute to improve the formulation of novel vaccines for AIT.

Keyphrases

dendritic cells
regulatory t cells
endothelial cells
air pollution
particulate matter
signaling pathway
drug delivery
cell proliferation
induced pluripotent stem cells
immune response
heavy metals
cancer therapy