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DNA nanocrane-based catalysts for region-specific protein modification.

Jordi F KeijzerH Bauke Albada
Published in: Organic & biomolecular chemistry (2024)
This paper describes the development and performance of catalytic DNA-based nanocranes for the controlled modification of wild-type proteins. We show that the position of the catalyst offers control over the region of modification, and that reversible interactions between the catalytic structure and thrombin enable trigger-responsive modification, even in cell lysate.
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