The stem cell organisation, and the proliferative and gene expression profile of Barrett's epithelium, replicates pyloric-type gastric glands.

Danielle L LaveryAnna M NicholsonRichard PoulsomRosemary JefferyAlia HussainLaura J GayJanusz A JankowskiSebastian S ZekiHugh BarrRebecca HarrisonJames GoingSritharan KadirkamanathanPeter DavisTimothy UnderwoodMarco R NovelliManuel Rodriguez-JustoNeil ShepherdMarnix JansenNicholas A WrightStuart A C McDonald

Published in: Gut (2014)

Barrett's shows the proliferative and stem cell architecture, and pattern of gene expression of pyloric gastric glands, maintained by stem cells showing gastric and intestinal differentiation: neutral drift may suggest that intestinal differentiation advances with time, a concept critical for the understanding of the origin and development of Barrett's oesophagus.

Keyphrases

stem cells
gene expression
dna methylation
cell therapy
genome wide
copy number
bone marrow
transcription factor