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Efficacy and Safety of Colistin versus Tigecycline for Multi-Drug-Resistant and Extensively Drug-Resistant Gram-Negative Pathogens-A Meta-Analysis.

Dina AbushanabZiad G NasrDaoud Al-Badriyeh
Published in: Antibiotics (Basel, Switzerland) (2022)
Within the limitations of this study, it can be concluded that there were no statistically significant differences in main efficacy outcomes between colistin and tigecycline monotherapies or combinations against MDR/XDR infections, except for lower rates of 30-day mortality with tigecycline and in-hospital mortality with colistin. Tigecycline was associated with favourable renal toxicity outcomes.
Keyphrases
  • multidrug resistant
  • drug resistant
  • acinetobacter baumannii
  • gram negative
  • klebsiella pneumoniae
  • oxidative stress
  • risk factors
  • type diabetes
  • pseudomonas aeruginosa
  • metabolic syndrome
  • weight loss
  • glycemic control