Bacterial and viral respiratory tract microbiota and host characteristics in adults with lower respiratory tract infections: a case-control study.
Bastiaan W HaakXanthe BrandsMark DavidsHessel Peters-SengersRobert F J KullbergRobin van HoudtFloor HugenholtzDaniël R FaberHans L ZaaijerBrendon P SciclunaTom van der PollW Joost WiersingaPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
Relative proportions of different bacteria and viruses in the nasopharynx can be leveraged to diagnose CAP and identify etiologic agent(s) in adult patients. Such data can inform the development of a microbiota-based diagnostic panel used to identify CAP patients and causative agents from nasopharyngeal samples, potentially improving diagnostic specificity, efficiency, and antimicrobial stewardship practices.