TGFβ-derived immune modulatory vaccine: targeting the immunosuppressive and fibrotic tumor microenvironment in a murine model of pancreatic cancer.

Maria Perez-PencoStine Emilie Weis-BankeAimilia SchinaMajken SiersbækMie Linder HübbeMia Aaboe JørgensenInés LecoqLucia Lara de la TorreSimone Kloch BendtsenEvelina MartinenaiteMorten Orebo HolmströmDaniel Hargbøl MadsenMarco DoniaNiels ØdumLars GrøntvedMads Hald Andersen

Published in: Journal for immunotherapy of cancer (2023)

This study demonstrates the antitumor activity of TGFβ-derived multipeptide vaccination in a murine tumor model of PDAC. The data suggest that the vaccine targets immunosuppression and fibrosis in the TME by polarizing the cellular composition towards a more pro-inflammatory phenotype. Our findings support the feasibility and potential of TGFβ-derived peptide vaccination as a novel immunotherapeutic approach to target immunosuppression in the TME.

Keyphrases

transforming growth factor
systemic sclerosis
risk assessment
cancer therapy
artificial intelligence