Potential SARS-CoV-2 Immune Correlates of Protection in Infection and Vaccine Immunization.
Yongjun SuiYonas BekeleDavid M MoorePublished in: Pathogens (Basel, Switzerland) (2021)
Both SARS-CoV-2 infections and vaccines induce robust immune responses. Current data suggested that high neutralizing antibody titers with sustained Th1 responses might correlate with protection against viral transmission and disease development and severity. In addition, genetic and innate immune factors, including higher levels of type I interferons, as well as the induction of trained immunity and local mucosal immunity also contribute to lower risk of infection and amelioration of disease severity. The identification of immune correlates of protection will facilitate the development of effective vaccines and therapeutics strategies.
Keyphrases
- sars cov
- innate immune
- immune response
- respiratory syndrome coronavirus
- small molecule
- electronic health record
- dendritic cells
- copy number
- resistance training
- big data
- risk assessment
- gene expression
- dna methylation
- machine learning
- ulcerative colitis
- body composition
- artificial intelligence
- bioinformatics analysis