17β-Estradiol reduces mitochondrial cAMP content and cytochrome oxidase activity in a phosphodiesterase 2-dependent manner.

Sofya PozdniakovaMariona Guitart-MampelGloria GarrabouGiulietta Di BenedettoYury LadilovVera Regitz-Zagrosek

Published in: British journal of pharmacology (2018)

17β-estradiol reduced the basal level of mitochondrial cAMP content and cytochrome oxidase activity in a sAC-independent but in a PDE2-dependent manner. The results suggest a role of 17β-estradiol-induced activation of NO signalling in the regulation of mitochondrial cAMP content. Our study adds a new aspect to the complex action of oestrogens on mitochondrial biology, that is relevant to hormone replacement therapy.

Keyphrases

diabetic rats
oxidative stress
replacement therapy
binding protein
smoking cessation
protein kinase
endothelial cells
high glucose