Increased Risk of Preeclampsia in Women With a Genetic Predisposition to Elevated Blood Pressure.

Anna Kivioja Elli Toivonen Jaakko S TyrmiSanni RuotsalainenSamuli Ripatti Heini Huhtala Tiina J JääskeläinenSeppo HeinonenKajantie EeroJuha KereKatja KivinenAnneli PoutaTanja Saarela Finnpec Hannele Laivuori

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

Our results suggest that HBP-PRS is associated with an increased risk of preeclampsia, recurrent preeclampsia, and preeclampsia with severe features. Furthermore, women with HBP-PRS present higher BP values during pregnancy. The results strengthen the evidence pointing toward the role of genetic variants associated with BP regulation in the etiology of preeclampsia, especially its more severe forms.

Keyphrases

early onset
blood pressure
pregnancy outcomes
heart rate
type diabetes
pregnant women
dna methylation
copy number
drug induced