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Too close for comfort? Endomembranes promote missegregation by enclosing lost chromosomes.

Lisa DonkerSusana A Godinho
Published in: The Journal of cell biology (2022)
Correct segregation of chromosomes during mitosis is essential to prevent aneuploidy. In this issue, Ferrandiz et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202203021) show that endomembranes can promote chromosome missegregation by "ensheathing" misaligned chromosomes, preventing their integration into the metaphase plate. Their findings point toward endomembranes as a potential risk factor for aneuploidy.
Keyphrases
  • single cell
  • cell therapy
  • copy number
  • mesenchymal stem cells
  • climate change
  • genome wide