Perivascular tissue resident memory T cells as therapeutic target in multiple sclerosis.
Joost J F M SmoldersNina L FransenCheng-Chih HsiaoJörg HamannInge HuitingaPublished in: Expert review of neurotherapeutics (2020)
Recent findings point toward the perivascular space as an immunological hotspot, which could be targeted in order to suppress a contribution of TRM cells to ongoing white matter lesion activity in advanced progressive MS. The authors discuss approaches, which may be explored to suppress TRM-cell reactivation in the perivascular space.