Impaired functional capacity of fetal endothelial cells in preeclampsia.
Lars BrodowskiJennifer BurlakovSarah HassConstantin von KaisenbergFrauke von Versen-HöynckPublished in: PloS one (2017)
Reduced functional abilities of fetal endothelial cells from preeclamptic pregnancies suggests that disease pathways, possibly originating from the dysfunctional placenta, negatively impact fetal endothelium. The neutral effect of 1,25(OH)2 vitamin D3 contrasts with previous findings that vitamin D rescues the poor migration, proliferation and tubule formation exhibited by cord blood fetal endothelial progenitor cells from preeclamptic pregnancies. Further investigations to distinguish pathways by which offspring exposed to preeclampsia are at risk for cardiovascular disease are needed.
Keyphrases
- endothelial cells
- cord blood
- cardiovascular disease
- pregnancy outcomes
- early onset
- preterm birth
- high glucose
- signaling pathway
- gestational age
- nitric oxide
- vascular endothelial growth factor
- adipose tissue
- pregnant women
- metabolic syndrome
- coronary artery disease
- skeletal muscle
- insulin resistance
- cardiovascular risk factors