In vitro evaluation of a novel oxygen-generating biomaterial for chronic rhinosinusitis therapy.

Dong-Jin LimDaniel SkinnerJohn M WestSamrath AyinalaShaoyan ZhangJessica W Grayson Bradford A Woodworth Do-Yeon Cho

Published in: International forum of allergy & rhinology (2021)

A novel OGB (CPO-CA-BW complex) exhibited sustained oxygen release over 7 days without significant cytotoxicity after 24 h in vitro. Preclinical studies evaluating the efficacy of OGB in CRS are warranted, especially for potential therapy in an obstruction-based CRS model.

Keyphrases

chronic rhinosinusitis
stem cells
bone marrow
climate change
mesenchymal stem cells
case control