Interaction of base excision repair gene polymorphism and estrogen-DNA adducts in breast cancer risk among East Asian women.

Hsing-Wu ChenWen-Hung KuoYen-Shen LuI-Chun ChenFu-Chang HuMing-Yang WangMuhammad ZahidEleanor G RoganAnn-Lii ChengChing-Hung Lin

Published in: Breast cancer research and treatment (2024)

APEX1_rs1130409 (GT/GG versus TT) polymorphisms, which are related to decreased BER activity, combined with an increased ratio of estrogen-DNA adducts, increase the risk of breast cancer in East Asian women.

Keyphrases

breast cancer risk
circulating tumor
cell free
polycystic ovary syndrome
single molecule
estrogen receptor
pregnancy outcomes
pregnant women
cervical cancer screening
metabolic syndrome
adipose tissue
insulin resistance