The pharmacological treatment and management of hyperhidrosis.
Anna CampanatiStamatios GregoriouAdamantia Milia-ArgytiGeorge KontochristopoulosGiulia RadiDiotallevi FedericoEmanuela MartinaAnnamaria OffidaniPublished in: Expert opinion on pharmacotherapy (2022)
Idiopathic hyperhidrosis, regardless of the site of involvement, remains a functional disorder that places a significant burden on patients. After balancing efficacy against adverse events, systemic therapy, although off-label for all forms of hyperhidrosis, can be an added therapeutic option for patients with insufficient response to topical treatment. Until the pathophysiological mechanisms underlying hyperhidrosis are clear and the etiological therapeutic approach becomes realistic, the greatest challenge in the therapeutic management of hyperhidrotic patients seems to be the search for the most convenient combination between different therapeutic modalities (topical and systemic agents, and botulinum toxins) to achieve long-term control of the disease symptoms.