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Mendelian randomization study of diabetes and dementia in the Million Veteran Program.

Elizabeth M LitkowskiMark W LogueRui ZhangBrian R CharestEthan M LangeJohn E HokansonJulie A LynchMarijana VujkovicLawrence S PhillipsRichard L HaugerLeslie A LangeSridharan Raghaven
Published in: medRxiv : the preprint server for health sciences (2023)
We found evidence of causality between diabetes and dementia using a one-sample MR study, with access to individual level data, overcoming limitations of prior studies utilizing two-sample MR techniques.
Keyphrases
  • type diabetes
  • mild cognitive impairment
  • cardiovascular disease
  • magnetic resonance
  • cognitive impairment
  • emergency department
  • glycemic control
  • metabolic syndrome
  • machine learning
  • skeletal muscle