ASO-Based PKM Splice-Switching Therapy Inhibits Hepatocellular Carcinoma Growth.
Wai Kit MaDillon M VossJuergen ScharnerAna S H CostaKuan-Ting LinHyun Yong JeonJohn E WilkinsonMichaela JacksonFrank RigoC Frank BennettAdrian R KrainerPublished in: Cancer research (2022)
Antisense oligonucleotides are used to induce a change in PKM isoform usage in hepatocellular carcinoma, reversing the Warburg effect and inhibiting tumorigenesis.
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