Early Glomerular Hyperfiltration and Long-Term Kidney Outcomes in Type 1 Diabetes: The DCCT/EDIC Experience.

Mark E MolitchXiaoyu GaoIonut BebuIan H de BoerJohn LachinAndrew PatersonBruce PerkinsAmy K SaengerMichael SteffesBernard Zinmannull null

Published in: Clinical journal of the American Society of Nephrology : CJASN (2019)

Early hyperfiltration in patients with type 1 diabetes was not associated with a higher long-term risk of decreased GFR. Although glomerular hypertension may be a mechanism of kidney injury in DKD, higher total GFR does not appear to be a risk factor for advanced DKD.

Keyphrases

type diabetes
blood pressure
diabetic nephropathy
glycemic control
cardiovascular disease
endothelial cells