Organophosphonic Acid-Regulating Assembly of P V -Sb III Polyoxotungstate and Its Potential in Building a Dual-Signal Readout Electrochemical Aptasensor for Carcinogen Detection.

Template-directed assembly of giant cluster-based nanomaterials is an everlasting theme in cluster science. In this work, ethylenediamine tetramethylphosphonic acid [H 8 EDTPA = (POCH 2 (OH) 2 ) 4 C 2 H 4 N 2 ] and [B-α-SbW 9 O 33 ] 9- were, respectively, used as an organic template and an inorganic template to prepare an organophosphonic acid-regulating P V -Sb III -heteroatom-inserted polyoxotungstate aggregate [H 2 N(CH 3 ) 2 ] 5 Na 11 H 9 [CeW 4 O 10 (HEDTPA)SbW 15 O 50 ][B-α-SbW 9 O 33 ] 2 ·36H 2 O ( 1 ). Noteworthily, organophosphonic acid ligand not only works as an organic template leading to the assembly of a [HEDTPASbW 15 O 50 ] 14- building block but also further bridges the sandwich-type [CeW 4 O 10 (B-α-SbW 9 O 33 ) 2 ] 11- entity. To extend its potential application in electrochemical sensing properties, we prepared a three-dimensional 1 @EGO composite (EGO = reduced graphene oxide functionalized by ethylenediamine) with porous architecture and a prominent conducting ability. Furthermore, the 1 @EGO composite was explored as a modification material for glassy carbon electrodes to build a dual-signal readout electrochemical aptasensor for carcinogens, which shows much better detection performance for aflatoxin B1 compared with traditional single-signal biosensors.