Altered mitochondrial genome content signals worse pathology and prognosis in prostate cancer.

Anton M F KalsbeekEva K F ChanJudith GroganDesiree C PetersenWeerachai JaratlerdsiriRuta GuptaRuth J LyonsAnne-Maree HaynesLisa G HorvathJames G KenchPhillip D StrickerVanessa M Hayes

Published in: The Prostate (2017)

Contrary to other cancer types, prostate cancer tissue shows no universally depleted mtDNA content. Rather, the change in mtDNA content is highly variable, mirroring known prostate cancer genome heterogeneity. Patients with high mtDNA content have an unfavorable pathology, while a high mtDNA content in normal adjacent prostate tissue is associated with worse prognosis.

Keyphrases

prostate cancer
radical prostatectomy
mitochondrial dna
copy number
oxidative stress
genome wide
squamous cell carcinoma
gene expression
single cell
young adults