Air particulate matter SRM 1648a primes macrophages to hyperinflammatory response after LPS stimulation.
Anna GawdaGrzegorz MajkaBernadeta NowakMałgorzata ŚróttekMaria WalczewskaJanusz MarcinkiewiczPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2018)
Our data indicate that exposure of macrophages to low concentrations of PM may prime the cells to hyperinflammatory response upon contact with LPS. Further studies are necessary to explain whether the exposure of patients suffering from chronic inflammatory diseases to particulate matter is responsible for the exacerbation of clinical symptoms during bacterial infections.
Keyphrases
- particulate matter
- air pollution
- end stage renal disease
- inflammatory response
- ejection fraction
- induced apoptosis
- newly diagnosed
- chronic obstructive pulmonary disease
- anti inflammatory
- peritoneal dialysis
- cell cycle arrest
- electronic health record
- big data
- depressive symptoms
- signaling pathway
- cell death
- risk assessment
- cell proliferation
- deep learning
- heavy metals
- patient reported
- artificial intelligence
- data analysis
- extracorporeal membrane oxygenation