Correlation Between Early Trends of a Prognostic Biomarker and Overall Survival in Non-Small-Cell Lung Cancer Clinical Trials.
Hugo LoureiroTheresa M KolbenAstrid KiermaierDominik RüttingerNarges AhmidiTim BeckerAnna Bauer-MehrenPublished in: JCO clinical cancer informatics (2023)
We describe a pipeline to predict trial OS HRs using emulated aNSCLC studies and their early OS and OS biomarker trends. The method has the potential to accelerate and improve decision making in drug development.