Digging into the Sequential Space of Thiolactone Precision Polymers: A Combinatorial Strategy to Identify Functional Domains.

Sensu CelasunDario RemmlerTimm SchwaarMichael G Weller Filip E Du Prez Hans G Börner

Published in: Angewandte Chemie (International ed. in English) (2019)

Functional sequences of precision polymers based on thiolactone/Michael chemistry are identified from a large one-bead one-compound library. Single-bead readout by MALDI-TOF MS/MS identifies sequences that host m-THPC that is a second generation photo-sensitizer drug. The corresponding Tla/Michael-PEG conjugates make m-THPC available in solution and drug payload as well as drug release kinetics can be fine-tuned by the precision segment.

Keyphrases

drug release
drug delivery
mass spectrometry
multiple sclerosis
air pollution
ms ms
cancer therapy
emergency department
drug induced