Tildrakizumab is an IL-23-inhibitor that has been approved to treat plaque psoriasis. However, few reports have become available on its efficacy profile in the real-world. Our objective was to study the mid-term efficacy of tildrakizumab in patients with moderate-to-severe psoriasis in the Spanish routine clinical practice setting. This was a retrospective multicenter study that included a total of 91 psoriatic patients on tildrakizumab. The mean Psoriasis Area and Severity Index (PASI) was 9.09 (SD, 5.30). The overall tildrakizumab survival rate was 93.47% for a mean treatment exposure of 30.18 weeks (SD, 16.57). No drug discontinuation was associated with drug tolerability, or adverse reactions. Absolute PASI ≤3 was reached by 91.3% and 96.5% of the patients on weeks 28 and 52, respectively. Response was not impacted by weight, age (>65), metabolic syndrome, presence of arthritis, or previous number of biological therapies used. Based on our own experience tildrakizumab is an effective strategy to treat plaque psoriasis and difficult-to-treat-areas.
Keyphrases
- end stage renal disease
- metabolic syndrome
- clinical practice
- ejection fraction
- newly diagnosed
- chronic kidney disease
- rheumatoid arthritis
- coronary artery disease
- prognostic factors
- atopic dermatitis
- adipose tissue
- body mass index
- high intensity
- adverse drug
- weight loss
- drug induced
- insulin resistance
- skeletal muscle
- disease activity
- double blind
- gestational age
- placebo controlled
- smoking cessation