Postlactational involution biomarkers plasminogen and phospho-STAT3 are linked with active age-related lobular involution.
Melody L Stallings-MannEthan P HeinzenRobert A VierkantStacey J WinhamTanya L HoskinLori A DenisonAziza NassarLynn C HartmannDaniel W VisscherMarlene H FrostMark E ShermanAmy C DegnimDerek C RadiskyPublished in: Breast cancer research and treatment (2017)
This is the first study to identify biomarkers of active LI. Our findings that plasminogen and pSTAT3 are significantly associated with LI suggest that they may represent signaling nodes or biomarkers of pathways common to the processes of postlactational involution and LI.