Age and multiparity related urethral sphincter muscle dysfunction in a rabbit model: Potential roles of TGF-β and Wnt-β catenin signaling pathways.

Mahadevan Raj RajasekaranJohnny FuMy-Uyen Lilly NguyenYaozhi WangMichael AlboValmik Bhargava

Published in: Neurourology and urodynamics (2018)

Age and multiparity related increase in fibrosis and atrophy of urethral sphincter muscles may contribute to impaired urethral closure function seen in old animals.

Keyphrases

urinary incontinence
cell proliferation
signaling pathway
epithelial mesenchymal transition
stem cells
skeletal muscle
transforming growth factor
oxidative stress
pi k akt
induced apoptosis
endoplasmic reticulum stress