What Is a Meaningful Difference When Using Infarct Volume as the Primary Outcome?: Results From the HERMES Database.
Leon A RinkelJohanna Maria OspelScott B BrownBruce C V CampbellDiederik W J DippelAndrew M DemchukCharles B L M MajoiePeter J MitchellSerge BracardFrancis GuilleminTudor G JovinKeith W MuirPhilip WhiteJeffrey L SaverMichael D HillMayank Goyalnull nullPublished in: Stroke (2024)
A difference of 2, 10, and 20 mL in 48-hour lesion volume, respectively, is associated with a 1%, 5%, and 10% absolute increase in the probability of achieving good functional outcome. These results can inform the design of future stroke trials that use 48-hour lesion volume as the primary outcome.