Pearls & Oysters: Case of Atypical Peripheral Nerve Findings Following Paclitaxel for Breast Cancer.

Neuromuscular ultrasound (NMUS) is a valuable tool in establishing a diagnosis of carpal tunnel syndrome (CTS), and can be particularly helpful in patients with clinical CTS but normal nerve conduction studies (NCS). This case involves the uncommon presentation of enlarged median nerves on NMUS with normal NCS in a breast cancer patient who developed chemotherapy induced peripheral neuropathy (CIPN) and CTS following taxane treatment. This case demonstrates that CTS should not be excluded based on electrodiagnostic studies alone, and comorbid CTS should be considered in patients receiving neurotoxic chemotherapy, even in the setting of normal NCS.