C-reactive protein perturbs alveolar bone homeostasis: An experimental study of periodontitis and diabetes in the rat.
Mengjiao ZhouXiaohui XuJie LiJie ZhouYao HeZiqi ChenShan LiuDuanjing ChenHan LiGuangyue LiJiao HuangGangyi YangTingwei ZhangJinglin SongPublished in: Journal of clinical periodontology (2022)
CRP inhibits osteogenesis and promotes osteoclastogenesis via PI3K/AKT signalling under diabetic and pro-inflammatory conditions, thus perturbing alveolar bone homeostasis.
Keyphrases
- pi k akt
- signaling pathway
- bone loss
- type diabetes
- bone mineral density
- bone regeneration
- cell cycle arrest
- cell proliferation
- soft tissue
- cardiovascular disease
- oxidative stress
- glycemic control
- postmenopausal women
- cell death
- metabolic syndrome
- wound healing
- lps induced
- body composition
- adipose tissue
- skeletal muscle